Frederick Chapman Robbins

Frederick Chapman Robbins
(1916)


American pediatrician and virologist who received (with John Enders and Thomas Weller) the 1954 Nobel Prize for Physiology or Medicine for successfully cultivating poliomyelitis virus in tissue cultures. This accomplishment made possible the production of polio vaccines, the development of sophisticated diagnostic methods, and the isolation of new viruses.
A graduate of Harvard University Medical School (1940), Robbins served in the United States, Italy, and North Africa during World War II (1942-46) as chief of the U.S. Army's 15th medical general laboratory virus and rickettsia section, where he investigated epidemics of infectious hepatitis, typhus, and Q fever.

After joining Enders and Weller at the Children's Hospital, Boston, in 1948, Robbins helped solve the difficult problem of propagating viruses--then known to grow only in living organisms--in laboratory suspensions of actively metabolizing cells in nutrient solutions. At that time it was believed that the virus responsible for poliomyelitis grew and multiplied only in mammalian nerve tissue, which is highly insusceptible to maintenance outside the living animal. By 1952 Robbins and his colleagues had succeeded in cultivating the virus in mixtures of human embryonic skin and muscle tissue suspended in cell cultures, dramatically demonstrating that the polio virus subsists in extraneural tissue, only later attacking the lower part of the brain and sections of the spinal cord.

Robbins served as director of the department of pediatrics and contagious diseases at the Cleveland Metropolitan General Hospital (1952-66) and as professor of pediatrics (1952-80) and dean (1966-80) at the Case Western Reserve University School of Medicine, Cleveland, Ohio.